Biography
Biography: Natalie Rasgon
Abstract
In the United States, it is estimated that approximately 50% of the population aged 50 years and older have a diagnosis of majorrndepression. 5.3 million Americans of all ages carry a diagnosis of dementia and 29.1 million have diabetes. It is not a coincidencernthen that these three Ds (diabetes, depression, and dementia) are so prevalent in our society. The reciprocal links between thernnervous system and endocrine systems underlie changes in the brain and body in both depressive illness and diabetes. Depressiverndisorder is associated with blunted central serotonin release, which, in turn, has been associated with metabolic dysfunction. Inrnaddition, inflammatory responses are widely implicated in the pathophysiology of diabetes and cardiovascular disease, as well asrnin cognitive impairment. Several other mediators of the reciprocal interaction between the CNS and insulin resistance includernglucocorticoids (cortisol), insulin, serotonin, and glutamate among others. While insulin affects hippocampal structures involvedrnin body weight regulation, it also influences memory processing. It is important to understand that diabetes, depression, andrndementia represent complex psychoneuroendocrine conditions requiring complex multisystem approach to their prevention andrntreatment.
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