Saule T Turuspekova
Kazakh National Medical University, Kazakhstan
Title: Effect of benfotiamine on cognitive function in patients with chronic alcoholism
Biography
Biography: Saule T Turuspekova
Abstract
It is known that alcohol remains the predominant form of addictive diseases worldwide. Alcohol use is a major risk factor for mortality in men aged 15-59 years.The basis of alcoholic nervous system disorders are neyrometabolizm, the development of which is related to pathogenic factors: nutritional, glutamatergic factor (excitotoxic effects of glutamate), GABAergic factor (reduction of GABA in nerve tissue).The highest value in the alimentary pathogenic mechanism is deficiency of thiamine (vitamin B1).
Objective: To evaluate the efficacy of benfotiamine for the correction of cognitive functions in patients with chronic alcoholism.
Material and Methods: Observed 68 patients with chronic alcoholism lasting no more than 10 years aged 25-50 years. To determine the degree of cognitive impairment used Mini-Mental State Examination (MMSE), a brief scale of the Montreal Cognitive Assessment (MoCA), Mini-Cog test, proofreading test Bourdon, test for mirroring, test for reciprocal coordination. Under supervision there were 2 groups: 1st - 53 patients who received 300 mg benfotiamine; 2 rd-15 control patients treated according to the protocol.
Results: more than 83% of patients with chronic alcoholism identified cognitive impairment. According to MoCA average value was 20,8 points. There was a significant positive dynamics of cognitive functions according to the MoCA test in the intervention group (from 20,8 to 24,6 points) compared with controls (20,8- 21,3 ). Also, there was an improvement in terms of proofreading Bourdon samples and other tests.
Conclusions: Thus, the dynamics of the research shows the positive effect of receiving benfotiamine on cognitive function in patients with chronic alcoholism.